/* 
*  CSS TABLE OF CONTENTS
*   
*  1.0 - Reset
*  2.0 - Fonts
*  3.0 - Globals
*  4.0 - Color Palette
*  5.0 - Header
*  6.0 - Body
*    6.1 - Nav Menu
*    6.2 - Imagery
*  7.0 - Footer
*/

/*** 1.0 - Reset ***/

/*** 2.0 - Fonts ***/

@font-face {
  font-family: "CeraPro";
  src: local("CeraPro");
  src: url("../fonts/CeraPro-Regular.eot");
  src: url("../fonts/CeraPro-Regular.eot?#iefix") format("embedded-opentype"),
    url("../fonts/CeraPro-Regular.woff") format("woff"),
    url("../fonts/CeraPro-Regular.woff2") format("woff2");
  font-weight: normal;
  font-style: normal;
}

@font-face {
  font-family: "CeraPro";
  src: local("CeraPro");
  src: url("../fonts/CeraPro-Medium.eot");
  src: url("../fonts/CeraPro-Medium.eot?#iefix") format("embedded-opentype"),
    url("../fonts/CeraPro-Medium.woff") format("woff"),
    url("../fonts/CeraPro-Medium.woff2") format("woff2");
  font-weight: 500;
}

@font-face {
  font-family: "CeraProBold";
  src: local("CeraProBold");
  src: url("../fonts/CeraPro-Bold.eot");
  src: url("../fonts/CeraPro-Bold.eot?#iefix") format("embedded-opentype"),
    url("../fonts/CeraPro-Bold.woff") format("woff"),
    url("../fonts/CeraPro-Bold.woff2") format("woff2");
  font-weight: bold;
  font-style: bold;
}

@font-face {
  font-family: "CeraProLight";
  src: local("CeraProLight");
  src: url("../fonts/CeraPro-Light.eot");
  src: url("../fonts/CeraPro-Light.eot?#iefix") format("embedded-opentype"),
    url("../fonts/CeraPro-Light.woff") format("woff"),
    url("../fonts/CeraPro-Light.woff2") format("woff2");
  font-weight: normal;
  font-style: normal;
}

/*** 3.0 - Globals ***/
.linkBold, .linkBold a{
  font-weight: bold;
  color:#ef426f!important;
}
.linkBold a:hover{
  text-decoration: underline;
  color:#ef426f;
}
.subFootContainer{
  padding-left: 120px;
  width: 85%;
}

.isi-modal a:hover {
  text-decoration: underline!important;
  color: #EF426F!important;
}
.footer a:hover{
  color:#EF426F;
  text-decoration: underline;
}
h1 {
  text-transform: uppercase;
}
h4 {
  color: #ef426f;
}
.isi-popup h2 {
  color: #ef426f;
  font-size: 1.125em;
  font-weight: bold;
  text-transform: uppercase;
}
.isi-modal h2 {
  color: #ef426f;
  font-size: 1.7em;
  text-transform: uppercase;
  font-weight: 600;
}
body.isi-modal {
  margin-bottom: 0em;
}
.isi-modal {
  padding: 4em 11em;
}

/* .isi-modal-video {
  padding: 4em 11em;
} */
.isi-modal .padModTop {
  padding-top: 1em;
}
.isi-modal .padModBottom {
  padding-bottom: 0.1em;
}
.isi-modal a {
  color: #ef426f;
  text-decoration: none;
}
.isi-modal a:hover {
  color: #ef426f;
  text-decoration: underline!important;
}
.numberList {
  color: #ef426f;
  font-weight: bold;
}
.ref-modal {
  padding: 25px;
  display: block;
  margin-left: 40px;
}
.ref-modal h2 {
  color: #ef426f;
  font-size: 1.7em;
  text-transform: uppercase;
  padding-bottom: 15px;
  font-weight: bold;
}
/*** 4.0 - Color Palette ***/

/*** 5.0 - Header ***/
.html {
  height: 100% !important;
  padding: 0;
  margin: 0;
}

#title {
  margin: 0.6em 8em;
  line-height: 1.6em;
  font-size: 1.125em;
  font-weight: 600;
  color: #ef426f;
  letter-spacing: 4px;
  text-transform: uppercase;
}
.logo {
  /* height:2.4em; */
  /* margin-top: 0.4em;
  margin-right: 0.5em; */
  width: 154.3px;
  cursor: pointer;
}
.header {
  position: fixed;
  top: 0;
  left: 0;
  background-color: #ffffff;
  width: 100%;
  z-index: 9999;
}

.arrow-right {
  opacity: 0;
  position: fixed;
  transition: all 0.5s ease;
  right: -1.875em;
  top: calc(50% - 3.6em);
  /* padding: 30px 85px 30px 10px; */
  padding: 20px 85px 17px 0px;
  font-size: 3em;
  color: #ffffff;
  background-color: #59d7c4;
  border-radius: 10em;
  cursor: pointer;
  z-index: 8888;
}

.arrow-left {
  position: fixed;
  left: -1.875em;
  top: calc(50% - 3.3em);
  transition: all 0.5s ease;
  background-color: #59d7c4;
  color: #ffffff;
  /* padding: 0.1em 0.1em 0.1em 1.7em; */
  /* padding: 30px 10px 30px 85px; */
  padding: 20px 0px 17px 85px;
  font-size: 3em;
  border-radius: 3em;
  opacity: 0;
  cursor: pointer;
  z-index: 8888;
}

.hide-arrow {
  opacity: 0;
}

.show-arrow {
  opacity: 1;
  z-index: 99999;
}
/*** 6.0 - Body ***/

body {
  color: #5b6770;
  font-family: CeraPro, Helvetica Neue, Helvetica, Arial, sans-serif;
  line-height: 1.2;
  font-size: 1em;
  padding: 0;
  margin: 0;
  text-shadow: 1px 1px 1px rgba(0, 0, 0, 0.004);
  text-rendering: optimizeLegibility !important;
  -webkit-font-smoothing: antialiased !important;
  min-height: 100%;
}


/*** 6.1 - Nav Menu ***/
nav {
  position: fixed;
  top: 0px;
  left: 0px;
  min-height: 3em;
  z-index: 10000;
  min-width: 7em;

  overflow: hidden;
}
nav input {
  display: none;
}
nav input:checked ~ label span:last-child {
  display: none;
}
nav input:not(:checked) ~ label span:first-child {
  display: none;
}
nav i {
  font-size: 2.5em;
}
nav label table {
  line-height: 1.2;
}
nav label table tr td {
  vertical-align: middle;
}
nav .nav-menu-text {
  font-size: 0.67em;
  text-transform: uppercase;
  font-family: CeraProBold,Helvetica Neue,Helvetica,Arial,sans-serif; 
}
nav .close {
  padding-left: 1.7em;
}
nav label {
  display: block;
  position: absolute;
  font-weight: bolder;
  right: 0px;
  top: 0px;
  user-select: none;
  width: 8.1em;
  height: 3em;
  text-align: center;
  padding-left: 2em;
  background: #e33a6f;
  color: white;
  -webkit-border-top-right-radius: 0.4em;
  -webkit-border-bottom-right-radius: 0.4em;
  -moz-border-radius-topright: 0.4em;
  -moz-border-radius-bottomright: 0.4em;
  border-top-right-radius: 0.4em;
  border-bottom-right-radius: 0.4em;
  cursor: pointer;
}
nav .nav-main {
  width: 0;
  height: 0;
  overflow-x: hidden;
  transition: width 0.3s, height 0.3s ease;
}
.nav-holder-inner {
  background-color: #e33a6f;
  width: 100%;
  height: 100%;

  padding-top: 0em;
  transition: width 0.3s, height 0.3s ease;
  padding-bottom: 1em;
  margin-top: 0em;
  overflow-y: auto;
}
nav .nav-holder {
  background-color: #e33a6f;
  height: calc(100vh - 265px);
  width: 93%;
  padding-top: 2.6em;
  transition: width 0.3s, height 0.3s ease;
  padding-bottom: 1em;
  overflow-y: hidden;
}

nav input:checked ~ .nav-main {
  width: 33em;
  overflow: hidden;
}
nav ul {
  padding: 0;

  background: #e33a6f;
  margin: 0;
  list-style: none;
  margin-top: 0.58em;
}
nav li {
  margin: 0em;
  margin-top: 0.1em;
  margin-right: 3em;
  border-radius: 2em;
  white-space: nowrap;
  overflow-x: hidden;
}

nav ul > li > ul > li {
  padding: 0em 1em;
  margin-left: 1em;
}

nav ul > li > a {
  color: #ffffff !important;
  text-decoration: none;
  font-size: 1.3125em;
  font-weight: bold;
  display: block;
  padding: 0.4em;
  padding-left: 2.5em;
  transition: color 0.5s, background 0.5s;
}

nav ul > li > ul > li > a {
  color: #ffffff !important;

  text-decoration: none;

  font-size: 1em;
  font-weight: bold;
  display: block;

  transition: color 0.5s, background 0.5s;
}

.no-background {
  background: transparent !important;
}

.mm-active {
  background: rgba(255, 255, 255, 0.2);
}

/*** 7.0 - Content***/
.containerR{
  float:left; 
  max-width: 473px; 
  padding-left:45px
}
.main-iframe {
  position: absolute;
  top: 0;
  left: 0;
  width: 100%;
  height: calc(100% - 190px);
  overflow-x: hidden;
}

button,
a.button {
  border: none;
  outline: none;
  background: #ef426f;
  border-radius: 24.4px;

  font-size: 16px;
  font-weight: bold;
  color: #fff;
  padding: 10px 39px;
  margin: 20px 0 14px;
  cursor: pointer;
}

/*** 8.0 - Footer **/
.isi-popup {
  padding-top: 25px;
}
.footer {
  position: absolute;
  bottom: 0;
  padding: 0 4.5em;
  width: 100%;
  border-top: 1px solid #eeeeee;
}
.footer-info {
  background-color: #ffffff;
  height: 150px;
  overflow: hidden;
  
}
.footerH {
  height: 40px;
  overflow-y: auto;
}
.footer a {
  color: #ef426f !important;
  text-decoration: none;
  font-weight: bold;
}
.footer a:hover {
  color: #ef426f !important;
  text-decoration: underline;
}



/*** 9.0 - Modal **/
.modal {
  display: none;
}
.open-modal {
  display: block;
}

a.closeModalBtn {
  cursor: pointer;
  color: #fff !important;
  border: 1px solid #ef426f;
  border-radius: 30px;
  background: #ef426f;
  font-size: 3.4em;
  display: inline-block;
  line-height: 0px;
  padding: 20px 6px;
  margin-top: -18px;
  text-decoration: none;
}

.closeModalBtn:before {
  content: "×";
}
.modalChart {
  width: 100%;
  padding: 0px 13em;
  margin: 0;
  padding-top: 3em;
}

.margTopChart2{
  width: 833px;
}
.margTopChart3{
  width: 736px;
}
.margTopChartRoll{
  width: 914px;
  display: block;
  margin-left: auto;
  margin-right: auto;
  margin-top: 110px;
  
}
.modal.open-modal {
  width: 100%;
  height: 100%;
  position: fixed;
  top: 0;
  left: 0;
  z-index: 100001;
  display: -ms-flexbox;
  display: flex;
  -ms-flex-pack: center;
  justify-content: center;
  -ms-flex-align: center;
  align-items: center;
}
.modal.open-modal .backdrop {
  display: block;
  width: 100%;
  height: 100%;
  background: rgba(0, 0, 0, 0.6);
  position: fixed;
}

.modal.open-modal .modal-window {
  z-index: 2;
  background: #fff;
  /* box-shadow: 2px 2px 8px #ccc; */
  width: 90%;
  height: 88%;
  text-align: center;
  margin: 0 1.6rem;
}
.footerPadR {
  padding-right: 20px;
}
.footerH {
  line-height: 40px;
}
/*** 10 - media ***/

@media (max-width: 480px) {
  .headline-hero {
    font-size: 1.275rem;
  }
  .headlineWidth {
    width: 100%;
  }
 .home-section .btnHome {
  margin-left: 2.5em;
 }
 .home-section h2 {
  margin-top: 117px;
 }
 .isi-modal h2 {
  font-size: 1.2em;
}
 .subHeadContainerHome {
    height: 6em!important;
    width: 27em;
  }
  .padL5{
    padding-left: 0;
  }
  .w150{
    width: 100%!important;
  }
  .title32{
    padding-top:0px;
    font-size: 3em;
  }
  .headline-2 sup {
    top: -0.3em!important;
  } 
  .subFootContainer{
    padding-left: 0px;
    width: 100%;
  }
  .containerR{
    float:left; 
    max-width: 100%; 
    padding-left:0px
  }
  .piContainer{
    width: 100%!important;
  }
  .moaVideo{
    padding: 0 10px;
  }
  a.closeModalBtn {
    padding: 17px 6px; 
  }
  .w325 img.mobimg{
    width: 100%;
  }
  .greenCallout3 sup{
    font-size: 0.45rem;
    top: -0.4em;
  }
  .greenCallout3 sup{
    font-size: 0.45rem;
    top: -0.4em;
  }
  .headline-hero sup {
    top: -1em;
}
  .takChart2{
    width: 100%!important;
    margin-left: auto!important;
    margin-right: auto!important;
    display: block;
  }
  
  .greenCalloutStudy {
    width: 100%!important;
    height: 46px;
    border-radius: 12.5px;
    background-color: rgba(44, 213, 196, 0.1);
    display: block;
    margin-left: auto!important;
    margin-right: auto!important;
    margin-top: 19px;
  }
  .patientContainer {
    padding-left: 0px;
  }
  .btnArrowNext{
    padding-left: 500px;
    margin-top: 0;
    position: relative;
  }
  .btnArrowPrev{
    padding-left: 0px;
    position: relative;
    margin-top: 0;
  }
  .homeName{
    display:none;
  }
  .home-section h2{
    margin-top: 200px;
  }
  .isi-modal {
    padding: 0 2em;
  }
  .greenCallout p .greenCalloutStudy p{
    font-size: 10px;
  }
  .takChart{
    padding-left: 0px;
    padding-right: 0px;
  }
  .mobCenter{
    text-align: center!important;
  }
  .isi-modal {
    padding: 0 2em;
  }
  /* smartphones, iPhone, portrait 480x320 phones */
  nav input:checked ~ .nav-main {
    width: 24em;
    height: calc(100vh);
  }

  nav .nav-holder {
    height: calc(100vh);
  }
  nav li {
    margin-right: 0.2;
    margin-right: 0.2em;
  }

  nav ul > li > ul > li {
    margin-left: 0.2em;
  }

  nav ul > li > a {
    padding: 0;
    padding-left: 0.8em;
  }

  nav ul > li > ul > li > a {
    color: #ffffff !important;
    padding: 0;
  }

  .footer-info {
    
    height: 150px;
    overflow-x: hidden;
    overflow-y: auto;
  }
  .footerH {
    height: 40px;
    overflow-y: auto;
    line-height: 1.4em;
  }

  .footer {
    
    padding: 0 0.8em;
    
  }

  body {
    line-height: 1.4em;
    font-size: 0.7em;
    
  }
  
  .isi-popup h2 {
    
    font-size: 0.7em;
    
  }
  .isi-popup p {
    font-size:0.875em;
  }
  .isi-modal h2 {
    
    font-size: 0.7em;
    
  }

  #title {
    margin: 0.4em 0 0 9em;
    line-height: 1.6em;
    font-size: 0.9em;
    
    
  }

  .arrow-right {
    
    padding: 30px 55px 30px 10px;
    
  }
  
  .arrow-left {
    
    padding: 30px 10px 30px 55px;
    
  }
  

  .modalChart{
    padding: 0px 3em;
  }

  .logo {
    /* height:2.4em; */
   width:50px;
  }
}
.btnArrowNext{
  margin-top: -246px;
  display: block;
  right: 0;
  float: right;
}
.btnArrowPrev{
  padding-left: 0px;
  position: absolute;
  margin-top: -260px;
}
@media (max-width: 640px) {
  .w150{
    width: 100%!important;
  }
  .subFootContainer{
    padding-left: 0px;
    width: 100%;
  }
  .containerR{
    float:left; 
    max-width: 100%; 
    padding-left:0px
  }
  .moaVideo{
    padding: 0 10px;
  }
  .w325 img.mobimg{
    width: 100%;
  }
  .headline-hero sup {
    top: -1em;
}
  .takChart2{
    width: 100%!important;
    margin-left: auto!important;
    margin-right: auto!important;
    display: block;
  }
  
  .greenCalloutStudy {
    width: 100%!important;
    height: 46px;
    border-radius: 12.5px;
    background-color: rgba(44, 213, 196, 0.1);
    display: block;
    margin-left: auto!important;
    margin-right: auto!important;
    margin-top: 19px;
  }
  .patientContainer {
    padding-left: 0px;
  }
  .btnArrowNext{
    padding-left: 500px;
    margin-top: 0;
    position: relative;
  }
  .btnArrowPrev{
    padding-left: 0px;
    position: relative;
    margin-top: 0;
  }
  .home-section h2{
    margin-top: 200px;
  }
  .isi-modal {
    padding: 0 2em;
  }
  .greenCallout p, .greenCalloutStudy p{
    font-size: 10px;
  }
  .mobCenter{
    text-align: center!important;
  }
  .isi-modal {
    padding: 0 2em;
  }
  .btnArrowNext{
    padding-left: 300px;
}
.btnArrowPrev{
  padding-left: 10px;
}
  .smallFoot{
    margin-left: 0px!important;
  }
  .margTopChartRoll{
   padding: 0px 20px;
  }
  .imgMob, .videoContainer,.margTopChartDosing, .margTopChart3, .colImage, .margTopChartRoll, .patientContainer, .untreatedHeader, .moaContainer, .imgMob{
    width: 100%!important;
  }
  .flushRight{
    display:none;
  }
  .pad50, .pad70, .padRightRow,.padLR,.takChart,.preventionChart, .pad110{
    padding: 0!important;
  }
  .imgCenter {
    width: 100%;
    margin: 5px 0 0 0px;
}
.patientContainer {
  padding-left: 0px!important;
}
  
  .margTopChartDosing{
    width: 100%;
  }
  .modalChartDose{
    padding: 3em 4em!important;
    width: 100%!important;
  }
  /* portrait e-readers (Nook/Kindle), smaller tablets @ 600 or @ 640 wide. */
  .leftMarg{
    margin-left: 0px;
  }
  .greenCallout2 {
   width: 100%;
   margin: 19px 0px 10px 0px;

 }
  .colPercent {
    padding: 0 0px;
  }
  .col-1.mob{
    display:none;
  }
  .help-study-primary-endpoint .two-col-section {
    padding-left: 0em;
    padding-right: 0em;
  }
  .colRightPad{
    padding-left: 0px;
  } 

  /*Hide JB*/
  .homeName{
    display:none;
  }
  /*Font size*/

  .home-section h2{
    font-size: 2.75em;
    line-height: 33px;
  }
  .home-section p {
    font-size: 1.15em;
    line-height: 19px;
    margin-top: 0px;
  }
  .colPercent .fontLarge .fontMedium {
    font-size: 1.5rem;
    line-height: 1em;
  }
  .title40{
    line-height:1em;
  }
  .bullets sup{
    font-size: 0.45rem;
  }
  /*Container*/
  .subFooterList{
    margin-left: 0px!important;
  }
  .greenCallout, .greenCalloutStudy {
   width: 100%!important;
   margin: 19px 0px 10px 0px!important;
 }
 .greenCallout p, .greenCalloutStudy p {
  font-size: 12px;
  line-height: 1em;
 }
 .subFooterList ul.fontXSmall{
  padding-left:0px;
}
.listRow {
  margin: 20px 0 0 0px;
}
.padTopP{
  padding-top:30px;
}
 /*IMAGES SCALE*/
  .colImage{
    width: 90%;
  }
  .dosingChart, .takChart, .margTopChart, .margTopChart2, .margTopChart3, .margTopChart4, .margTopChart5, .zeroAttackChart, .preventionChart{
    width:100%!important;
    padding-left: 0px;
    padding-right: 0px;
    margin-left: 0px!important;
  }
  .left30{
    margin-left: 0px;
  }

  nav input:checked ~ .nav-main {
    width: 24em;
    height: calc(100vh);
  }

  nav .nav-holder {
    height: calc(100vh);
  }
  nav li {
    margin-right: 0.2;
    margin-right: 0.2em;
  }

  nav  ul > li > ul > li {
    margin-left: 0.2em;
  }

  nav  ul > li > a {
    padding: 0;
    padding-left: 0.8em;
  }

  nav  ul > li > ul > li > a {
    color: #ffffff !important;
    padding: 0;
  }

  .footer-info {
    
    height: 150px;
    overflow-x: hidden;
    overflow-y: auto;
  }
  .footerH {
    height: 40px;
    overflow-y: auto;
    line-height: 1.4em;
  }

  .footer {
    
    padding: 0 0.8em;
    
  }

  body {
    line-height: 1.4em;
    font-size: 0.7em;
    
  }
  
  .isi-popup h2 {
    
    font-size: 0.7em;
    
  }
  .isi-modal h2 {
    
    font-size: 1.2em;
    
  }

  #title {
    margin: 0.4em 0 0 9em;
    line-height: 1.6em;
    font-size: 0.9em;
    
    
  }

  .arrow-right {
    
    padding: 30px 55px 30px 10px;
    
  }
  
  .arrow-left {
    
    padding: 30px 10px 30px 55px;
    
  }
  

  .modalChart{
    /* padding:0!important; */
  }

  .logo {
    /* height:2.4em; */
   width:50px;
  }
}
.footer .container-full .footerH {
  font-size: 14px;
}
@media (max-width: 1025px) {
  .w150{
    width: 100%!important;
  }
  .subFootContainer{
    padding-left: 0px;
    width: 100%;
  }
  .containerR{
    float:left; 
    max-width: 100%; 
    padding-left:0px
  }
  .moaVideo{
    padding: 0 10px;
  }
  .takChart2{
    width: 100%!important;
    margin-left: auto!important;
    margin-right: auto!important;
    display: block;
  }
  
  .greenCalloutStudy {
    width: 100%!important;
    height: 46px;
    border-radius: 12.5px;
    background-color: rgba(44, 213, 196, 0.1);
    display: block;
    margin-left: auto;
    margin-right: auto;
    margin-top: 19px;
  }
  .patientContainer {
    padding-left: 0px;
  }
  .btnArrowNext{
    margin-top: 0;
    position: relative;
    float:right;
  }
  .btnArrowPrev{
    padding-left: 0px;
    position: relative;
    float:left;
    margin-top: 0;
  }

  .footer .container-full .footerH {
    font-size: 10px;
  }
  .homeName{
    display:none;
  }
 
  .smallFoot{
    margin-left: 0px!important;
  }
  .imgMob, .videoContainer, .margTopChartDosing, .margTopChart3,.colImage, .margTopChartRoll, .patientContainer, .untreatedHeader, .moaContainer, .imgMob{
    width: 100%!important;
  }
  .pad50, .pad70, .padRightRow,.padL, .pad110{
    padding: 0!important;
  }
  .margTopChartRoll{
    padding: 0px 20px;
   }
   .flushRight{
    display:none;
  }
  .imgCenter {
    width: 100%;
    margin: 5px 0 0 0px;
}
.patientContainer {
  padding-left: 0px!important;
}
  .margTopChartDosing{
    width: 100%;
  }
  .modalChartDose{
    padding: 3em 4em!important;
    width: 100%!important;
  }
   /*Container*/
   .leftMarg{
     margin-left: 0px;
   }
   .greenCallout2 {
    width: 100%;
    margin: 19px 0px 10px 0px;

  }
   .mob{
    display:none;
  }
   .help-study-primary-endpoint .two-col-section {
    padding-left: 0em;
    padding-right: 0em;
  }
  .colPercent {
    padding: 0 0px;
  }
  .colRightPad{
    padding-left: 0px;
  } 
   .subFooterList{
    margin-left: 0px!important;
  }
  .greenCallout, .greenCallout3, .greenCalloutStudy {
   width: 100%!important;
   margin: 19px 0px 10px 0px!important;
 }
 .greenCallout p, .greenCallout3 p, .greenCalloutStudy p {
  font-size: 12px;
  line-height: 1em;
 }
 .subFooterList ul.fontXSmall{
  padding-left:0px;
}
.listRow {
  margin: 20px 0 0 0px;
}
/*Image scale*/
.dosingChart, .takChart, .margTopChart, .margTopChart2, .margTopChart3,.margTopChart4, .margTopChart5, .zeroAttackChart, .preventionChart{
  width:100%!important;
  padding-left: 0px;
  padding-right: 0px;
  margin-left: 0px!important;
}
.left30{
  margin-left: 0px;
}
.padTopP{
  padding-top:30px;
}
  /* portrait tablets, portrait iPad, landscape e-readers, landscape 800x480 or 854x480 phones */
  nav input:checked ~ .nav-main {
    width: 24em;
    height: calc(100vh);
  }

  nav .nav-holder {
    height: calc(100vh);
  }

  ::-webkit-scrollbar {
    -webkit-appearance: none;
    width: 7px;
  }
  
  ::-webkit-scrollbar-thumb {
    border-radius: 4px;
    background-color: rgba(0, 0, 0, .5);
    box-shadow: 0 0 1px rgba(255, 255, 255, .5);
  }
  
  nav li {
    margin-right: 0.2;
    margin-right: 0.2em;
  }

  nav  ul > li > ul > li {
    margin-left: 0.2em;
  }

  nav  ul > li > a {
    padding: 0;
    padding-left: 0.8em;
  }

  nav  ul > li > ul > li > a {
    color: #ffffff !important;
    padding: 0;
  }

  #title {
    margin: 0.4em 0 0 9em;
    line-height: 1.6em;
    font-size: 0.9em;
    
    
  }

  .logo {
    /* height:2.4em; */
   width:50px;
  }
}

@media (min-width: 1026px) {
  
  
  /* portrait tablets, portrait iPad, landscape e-readers, landscape 800x480 or 854x480 phones */
  nav input:checked ~ .nav-main {
    
    height: calc(100vh - 191px);
  }

  nav .nav-holder {
    /* height: calc(100vh); */
    height: 100%;
    
  }


}

/*Desktop JB*/
.colImage{
  width: 100%;
}
.zeroAttackChart{
  width: 971px;
}
.preventionChart{
  width: 922px;
}
.takChart{
  width: 1035px;
  margin-left: auto;
  margin-right: auto;
  padding-left: 70px;
  padding-right: 70px;
  display: block;
}
.takChart2{
  width: 1035px;
  margin-left: 116px;
  display: block;
}
.greenCallout {
  width: 1036px;
  height: 46px;
  border-radius: 12.5px;
  background-color: rgba(44, 213, 196, 0.1);
  display: block;
  margin-left: auto;
  margin-right: auto;
  margin-top: 19px;
}
.greenCalloutStudy {
  width: 1036px;
  height: 46px;
  border-radius: 12.5px;
  background-color: rgba(44, 213, 196, 0.1);
  display: block;
  margin-left: 116px;
  margin-top: 19px;
  
}
.subFooterList {
  margin-top: 0px;
  margin-left: 0px;
}
.margTopChart4{
  width: 601px
}
.margTopChart5{
  width: 1120px
}
.margTopChartDosing{
  width: 1122px;
  margin-top:30px;
}
.padLR{
  padding: 0 70px;
}
.homepagefootNote{
  font-size: 11px!important;
  font-weight: normal!important;
  padding-top: 0!important;
}
/*LISTS*/
ol.ref {
  padding-left:1.2em;
}
ol.ref li {
  padding: 5px;
  margin-left: 0px;
  color: #ef426f;
  font-weight: bold;
}
ol.ref li::marker {
  font-family: sans-serif; 
}

ol.ref li span {
  font-weight: normal;
  color: #5B6770;
}
.subFooter p{
  margin: 0 0 3px!important;
  color: #5b6770;
  font-weight: normal;
  line-height: 1.2em;
  text-align:left;
}
.asterix{
  font-size: 15px!important;
  position: relative;
  padding-left: 0.1em;
}
.supCall2{
  top: -0.15em!important;
  font-size: 0.85em!important;
}
.supXsmall{
  top: -0.4em!important;
}
.supXsmall2{
  top: -0.4em!important;
}
.supH2{
  top: -0.45em!important;
  padding-left: 1px;
}
.noMargTop{
  margin-top: 0px!important;
}
.btnSqr{
  border-radius: inherit;
}
.dosingChart{
  width: 729px;
}
.btnW{
  width: 280px;
  min-width: 280px;
  margin-left:0px;
  font-size:1em;
}
.btmM{
  margin-bottom: 1px;
  margin-top:18px;
}
.btnSpacer{
  padding-bottom: 30px;
}
.patientContainer{
  float:left;
  width:572px;
  padding-left:31px
}
.moaContainer{
  float:left; 
  width:360px
}
.content-topic{
  font-weight: bold;
}
.isitaklogo{
  width: 112px;
  height: 61px;
  margin-top: -17px;
}
.takLogoContainer{
  width: 113px;
}
.fontsmall{
  font-size: 9px;
}
.menuBold{
  font-weight: 900;  
}
.smallFoot{
  margin-left: 80px;
}
.supDef{
  top: -0.65em!important;
  font-size:9.6px!important;
}
.fontMont{
  font-family: 'Montserrat', sans-serif;
  font-size: 1.125em;
  margin-top: 0px;
}
.margL200{
  margin-left:200px;
}
.videoContainer{
    margin-left: auto;
    margin-right: auto;
    display: block;
    width: 1080px;
    margin-top: 10px;
}
.piContainer{
  margin-left: auto;
  margin-right: auto;
  display: block;
  width: 1080px;
  height: 100%;
  margin-top: 10px;
}
.moaVideo{
  display: block;
  margin-left: auto;
  margin-right: auto;
  position: relative;
  width: 100%;
}
.piPdf{
  position: relative; 
  margin-left:auto; 
  margin-right:auto; 
  display:block; 
  margin-top: 20px;
  width: 100%;
  height: 800px;
}
.takedaLogo{
  width: 104px;
  height: 56.4px;
}
.noLine{
  text-decoration: none!important;
}
.menuR{
  font-weight: normal;
  top: -0.25em;
  font-size:0.9em;
}
.w150{
  width: 150px;
}
.cross{
  font-size: 0.8em!important;
  font-weight: normal;
  top: -0.1em!important;
  position: relative;
}
.frontSup{
  top:0.13em!important;
  font-size: 1.1em!important;
  margin-left: -6px;
}
.frontSup1{
  top:0.13em!important;
  font-size: 1.1em!important;
  margin-left: -3px;
}
.frontSup2{
  top:-0.3em!important;
  font-size: 0.7em!important;
  margin-left: -6px;
}
.frontSup3{
  top:-0.5em!important;
  font-size: 0.6em!important;
  margin-left: -4px;
}
.frontSup4{
  top:0.13em!important;
  font-size: 1.1em!important;
  margin-left: -5px;
}
.frontSup5 {
  top: -0.3em!important;
  font-size: 1.1em!important;
  margin-left:-4px;
}
.frontSup6 {
  top: 0.1em!important;
  font-size: 1.1em!important;
  position: relative;
}
.padL5{
  padding-left: 5px;
}
.supCross{
  font-size: 1.3em!important;
  top: 0.3em!important;
  position: inherit;
}
.supAst {
  font-size: 1.6em;
  top: 0.4em!important;
  position: inherit;
}
.headline-2 sup{
  top: -0.7em;
}
.lMargSup{
  margin-left: -3px;
}
.colPadOnePath{
  padding: 0 40px;
}
.takLogoHeader{
  position:absolute;
  top: 4.35em;
  right: 1em;
  z-index:99;
}
.subHeadContainerHome{
  position:relative;
  height: 4.5em;
}
.margSub{
  margin-top: 0px!important;
  padding-top: 0px!important;
  line-height: 10px!important;
}
.item-1, 
.item-2 {
  position:absolute;
  top:0;
  left:0;

	animation-duration: 20s;
	animation-timing-function: ease-in-out;
	animation-iteration-count: infinite;
}

.item-1{
	animation-name: anim-1;
}

.item-2{
	animation-name: anim-2;
}


@keyframes anim-1 {
	0% { opacity: 0; }
  10.6%,39.5% { opacity: 1; }
  50%, 100% { opacity: 0; }
}

@keyframes anim-2 {
	0%, 50% { opacity: 0; }
  60.5%, 89.5% {  opacity: 1; }
  100% { opacity: 0; }
}


.hidden {
  display: none;
}
/*Image Swap*/
.visible-mobile {
  display: none !important;
}
@media (max-width: 489px) {
  .visible-mobile {
    display: block !important;
  }

  .hidden-mobile {
    display: none !important;
  }
}
 
/*FOOTER SCROLLBAR OVERRIDE*/
.mCSB_dragger .mCSB_dragger_bar {
  background-color: #fff!important;
  background-color: rgb(255 255 255 / 100%)!important;
}
.mCS-inset-3-dark.mCSB_scrollTools .mCSB_draggerRail {
  background-color: #5b6770;
  background-color: rgba(91, 103, 112, 0.5)!important;
  width: 0px!important;
}
.mCSB_scrollTools .mCSB_draggerContainer {
  position: absolute;
  top: 0;
  left: 0;
  bottom: 0;
  right: 0;
  height: auto;
  border-radius: 8px;
  background: #5b6770;
  width: 10px!important;
  opacity: .5;
}
.mCS-inset-3-dark.mCSB_scrollTools .mCSB_dragger .mCSB_dragger_bar{
  margin: 3px 2px!important;
}